Microdosing Cactus Guide 2021

What is Microdosing?

Microdosing is the act of consuming sub-perceptual (unnoticeable) amounts of a psychedelic substance



Many individuals who have integrated microdosing mescaline-containing cactus into their weekly routine report higher levels of creativity, more energy, increased focus, and improved relational skills, as well as reduced anxiety, stress, and even depression.


Why choose Cactus to Microdose?

Many users find mescaline more consistently reliable than LSD and psilocybin and find that the personal benefit can also be greater.


Self-experimenters around the world are reporting a much wider range of benefits. These include:

  • Personal insights

  • Mood enhancement

  • Increased empathy and creativity

  • Lifestyle changes

  • Lucid dreams [24][25][27]


Mescaline also has a much longer history of use, and this apparently goes for microdoses too. The Rarámuri Indians, for example, have long used small amounts of peyote while hunting, allowing them to stalk deer for days on end without rest.[26]


What Science Says about Microdosing Cactus

Research into mescaline’s psychotherapeutic potential is still limited, but renewed interest in the drug shows that it could successfully treat mental health disorders.


For Depression:

Studies suggest, for example, that mescaline may increase blood flow and activity in the prefrontal cortex, the area of the brain in charge of planning, problem-solving, emotional regulation, and behavior. Low activity in this area is linked to depression and anxiety, leading scientists to hypothesize that mescaline could help alleviate symptoms of these disorders.


Mescaline also activates serotonin and dopamine receptors, which could help boost mood and treat depression. In fact, one of the traditional therapeutic uses for peyote was as an antidepressant, and depression scores are reportedly low among members of the Native American Church, where peyote use is common.[44]


Some researchers have found that the antidepressant benefits of mescaline correlate to a subjects’ willingness to engage with the experience, to face themselves and to act upon the insights received. In one mid-century study, some of the most significant transformations or breakthroughs came about months after the experience itself, even if the initial psychedelic therapy session seemed to be a failure. In the context of psychotherapy, mescaline may also be useful for re-living or recalling repressed memories.


For Suicidal Thoughts:

Mescaline could also help reduce suicidal thoughts, according to researchers at the University of Alabama. Using data from the National Survey on Drug Use and Health, the researchers found that people who have used a psychedelic drug at least once in their life show lower rates of suicidal thinking.



For Anxiety:

A 2013 study also found that lifetime mescaline or peyote use was significantly linked to a lower rate of agoraphobia, an anxiety disorder where subjects perceive their surrounding environment to be threatening.


For Addiction:

Addiction is another promising application for mescaline’s therapeutic potential. As peyote, mescaline has long been used in traditional ceremonial contexts to treat alcoholism. It’s interesting to note that while alcohol abuse rates among the Navajo and other Native American tribes are said to be roughly twice the U.S. average, they are significantly lower among NAC members.[45][46][44] This correlation isn’t conclusive, of course, but research does suggest that there could be a more-than-causal link. In fact, a researcher at Harvard Medical School who has spent years studying peyote use found that the substance has reduced rates of alcoholism and drug abuse among Native Americans. He also concluded that the ceremonies themselves are an important element to the plant’s healing effects.


In traditional settings, mescaline has been used for alleviating symptoms of fever, headache, sunstroke, and arthritis.[47] Actually the cactus is traditionally seen as something of a cure-all and is sometimes taken daily. According to some Native Americans, the proper use of peyote renders all other medicines superfluous.[48] While there are key differences between modern Western medicine and the medico-religious approach of Native American mystics, clinical studies have supported mescaline’s role in pain relief, and in promoting the release of growth hormones.[49][50]


Personal Accounts of Microdosing

Some find it useful for treating the symptoms or even the underlying causes of depression, experiencing a sense of peace and calm without the “numbness” of conventional medications.[28]


In fact, it tends to have the opposite effect of actually sharpening the senses and enhancing mental clarity. One user remarked on how easy it was to enter a flow state on microdoses of mescaline, especially when playing the guitar:


“I would just be improvising and hit a couple notes that reminded me of a song and then I’d start with those and work my way through the rest of the riff just by memory.” [29]


As might be expected given the traditional Tarahumara use, there’s also a definite stimulant effect, perhaps more so than with LSD or psilocybin. This can be useful for physical endurance such as sports, hiking, manual labor, and so on.[31][32][24] And while it may act as an appetite suppressant, mescaline tends to lack the edginess of other stimulants. Indeed some users microdose it specifically to reduce feelings of anxiety, often with great success:


“I … used to have anxiety going to the checkout counter in a store, hated if anyone started small talk with me and planned out what I was going to say to the cashier, it was really bad. After I started taking microdoses of mescaline in the form of San Pedro powder, that all went away.”[33]


Increased empathy may have something to do with this. Many people feel a greater connection to others, for instance, and are often surprised at how freely conversations start to flow. [34][29][31][35]



How to Microdose

Experts in this area suggest different microdosing regimens. James Fadiman recommends taking a microdose once every three days: Take a microdose on Day 1. Then, do not take a microdose on Day 2 or Day 3. On Day 4, take another microdose.



Continue this process for several weeks.

For most people, morning is the best time because the beneficial effects will last throughout the day without interfering with sleep. It’s also helpful to take daily notes in a journal to observe the effects throughout this process and adjust accordingly—or just notice the positive changes.


It’s also important to follow your usual routine while microdosing. The purpose is to enhance your day-to-day existence by integrating microdoses into your routine, so don’t change what you normally do. However, when you try microdosing for the first time, take a day off from work and social commitments. This will give you a chance to notice any unusual effects before microdosing in a more public situation.


While it may seem like you would only feel the effects of the microdose on the days you actually take it, try to observe the effect on the two days between doses, too. Many people perceive increased feelings of flow, creativity, and energy the day after they microdose in addition to the day of microdosing.


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